Why Kratom Doesn’t Work For Some People?

Posted by: bill Category: Articles Comments: 0 Post Date: July 23, 2018

Why Kratom Doesn’t Work For Some People?

“Why doesn’t kratom work for me?” That’s a relatively common question and there are a host of different potential causes that can result in a lack of desired results.

Firstly, it’s important to understand what kratom is and how it works. Kratom is made from the dried kratom tree leaves (Mitragyna Speciosa). Asian cultures have been using kratom for generations to treat ailments such as anxiety, diarrhea and pain.

In recent years, kratom has become popular for its opiate-like properties, which are favored among people who are seeking relief from chronic pain. Kratom is also used as an aid for self-weaning from opiate medications.

Kratom is dried and ground into a fine powder, which can be brewed into a tea or packed into capsules. Some even eat it raw by mixing the powder with something sweet, such as apple sauce. Potent kratom extracts are also available, with more concentrated levels of mitragynine.

When it comes to the question of why kratom doesn’t work for some individuals, there are many potential causes. Notably, in a small percentage of people, kratom really doesn’t produce effects due to the presence of unique enzymes that rapidly and improperly metabolize the kratom. But the percentage of people who experience this problem is very low and this isn’t the only potential cause of a lack of kratom effects. In fact, there are many potential causes, so you’ll want to “troubleshoot” to rule out other potential issues that can create a situation where you fail to get the results you’re seeking.

Kratom powder quality

The quality of your kratom powder is a major consideration; one that should be at the top of your troubleshooting list. As is the case in any industry, there are some individuals who sacrifice quality in order to make money. Some suppliers sell kratom that’s sub-par in terms of quality; in some rare instances, the powder isn’t even kratom powder! In fact, a study revealed that as much as 10 percent of all kratom sold online fails to meet industry standards for quality.

Therefore, if you’re trying a new kratom supplier or brand, you may wish to ask another kratom aficionado to try the powder to verify its quality.

Kratom powder dosage

Like any medication or substance, the amount that you ingest determines the effect of the kratom powder. For legal reasons, many vendors don’t include dosing information on the package, so individuals are left to make an educated guess or turn to online sources, many of which are not accurate.

So it’s essential to ensure your dosage is correct. The minimum kratom dosage required to bring effects is three to four grams; the average dosage is between five to seven grams. Some require up to ten grams, though if you’re taking ten grams or more and don’t see any real impact, then it’s advisable to check into some other potential issues. Also remember that if you take kratom on an empty stomach, the effects will be amplified, whereas if you take it on a full stomach, a higher dosage will be required.

Kratom tolerance

Some individuals have a tolerance to kratom, even though they’ve never tried it before. This is called “cross tolerance.” Cross tolerance can occur if you routinely take opiates and painkillers, which increase your body’s tolerance to kratom.

In cases where cross tolerance is at play, some users may opt to temporarily decrease the amount of opiates to see if they achieve the desired effects. You may also try taking kratom before your next dosage of painkillers to see if the effects become more noticeable.

Alcohol and general wellness

If you’ve ingested alcohol or are otherwise unwell, then your body may not respond well to kratom. You may not see the desired effect or any effect.

Alcohol can dramatically impact kratom’s effects. Some say that a small amount of alcohol amplifies the effects, but a significant amount can result in adverse effects or the alcohol’s effects may overshadow any impact from kratom.

What’s more, physical health ailments such as a fever or sleep deprivation can create a situation where your body does not absorb and process the kratom properly, resulting in dramatically reduced effects.

Improper Kratom Storage

Improper storage of kratom can dramatically impact its potency and effects. The ideal conditions for kratom storage are the same as what you would utilize for a fine tea: it must be free of oxygen, humidity and UV light. This serves to maximize potency by preventing degradation and “staleness” that results from improper storage. Stale, improperly stored kratom can lose its potency rather quickly.

According to some researchers, the mitragynine compounds that are found in kratom are believed to undergo a gradual transformation into mitragynine pseudoindoxyl.  Mitragynine pseudoindoxyl has minimal painkilling properties, which results in kratom that simply won’t produce the desired effects.

Therefore, it’s important to use proper storage methods for your kratom. Most users opt to divide the kratom into small bags, containing enough for a day or two; this enables you to . Then, vacuum-seal the bags to remove the air; this will preserve freshness and halt the degradation process. The bags should then be placed into an opaque, light-blocking canister, which can be placed in the freezer. This ensures the kratom is stored in a cold, air-free and UV-free environment, which will result in optimal freshness and potency.

Enzymes, metabolizers and kratom

If you’ve performed a bit of “troubleshooting” and ruled out all of the aforementioned issues, then it’s likely that enzymes and metabolizers may be having an impact, resulting in little, if any, effect from kratom.

An enzyme called Cytochrome P450 2D6 – also called CYP2D6 — serves to process and metabolize the kratom. This enzyme is responsible for processing the kratom and generating the effects that you experience. Individuals who have a high level of this enzyme will enjoy more significant effects when they take kratom.  Individuals who have low levels of CYP2D6 would need to take a significant amount of kratom to feel any impact; even then, some individuals report that the effects are very minimal.

There is another enzyme, called CYP3A4, which serves like a mop of sorts; it “soaks up” and processes the kratom. This serves to make your body process the kratom quickly and it can result in dulled intensity and a shorter duration of the effects. So you want to have low levels of CYP3A4 in order to enjoy a good experience.

Notably, herbs and supplements can be used to suppress the latter enzyme. Also, there are some medications that can raise levels of CYP3A4, including anti-convulsion medications and mood stabilizing medications.

Unfortunately, if you’re among the individuals with low levels of the CYP2D6 enzyme, there are no real effective ways to boost it. In this case, it’s generally best to opt for a different herbal remedy that works better with your body’s chemistry.

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